HIV persistence in latently infected, resting CD4+ T cells is broadly considered a barrier to eradicate HIV. More by Reed E. S. Harrison. Please reconnect, https://doi.org/10.1021/acsmedchemlett.0c00302. Users are Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group. Binding assays and data analysis. You’ve supercharged your research process with ACS and Mendeley! Here, we propose to directly target C3d through small peptides mimicking the binding of its natural ligand, the complement regulator Factor H (FH). Get article recommendations from ACS based on references in your Mendeley library. 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Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information about Crossref citation counts. Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein. Assembling Pharma Resources to Tackle Diseases of Underserved Populations. Structure-Based Inhibitor Discovery of Class I Histone Deacetylases (HDACs). Here we report the discovery of a series of selective and potent class I HDAC inhibitors based on aryl ketones as a zinc binding group, which reversed HIV latency using a Jurkat model of HIV latency in 2C4 cells. from the ACS website, either in whole or in part, in either machine-readable form or any other form Description: ACS Publications introduced Just Accepted Manuscripts (JAMs) in 2009 in response to the community’s need to disseminate research findings more quickly. Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States, Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance. Our FH-inspired peptides call now for further optimization toward high-affinity binding and suggest that small peptides are promising as novel C3d biomarkers and therapeutic tools. These metrics are regularly updated to reflect usage leading up to the last few days. OR SEARCH CITATIONS My Activity. Get article recommendations from ACS based on references in your Mendeley library. For permission to reproduce, republish and The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. RETURN TO JUST ACCEPTED MANUSCRIPTS PREV Note NEXT. Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. 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